Unexplained Infertility

Couples who reach a year of no conception when trying for pregnancy are called infertile. Usually the next step is a battery of tests to determine what might be causing the issue. But 10-30% of couples actually are told ‘everything is fine,’ and that they have no issue that is causing the infertility.

Although over 800 research studies have been done trying to come up with solutions to the problem, few studies have really tried to understand what could have caused the problem to begin with.

Some of the research calls women with PCOS who have regular cycles as ‘unexplained’ infertility, but we do not.

Medication for ovulation is what is usually tried to resolve the infertility. The newest studies say that these couples can be treated with clomid or with letrozole, and there is not much difference between which medicine should be used. Actually some of the studies with the lowest doses of letrozole have the highest pregnancy rate per cycle.

Side effects to the use of these medicines includes: abdominal bloating, breast pain, hot flashes, constipation, and headaches.

Miscarriage rates, and rates of birth defects, are only slightly higher with medication ovulation induction as compared to couples that get pregnant naturally.

There are many solutions to infertility problems, see us early, and we can discuss your personal journey to motherhood and fatherhood.


Suzanne Trupin, MD, Board Certified Obstetrician and Gynecologist and owner of Women's Health Practice, Hada Cosmetic Medicine, and Hatha Yoga and Fitness

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