Our Gyno Health

Explaining Why You Have Uterine Fibroids

Uterine fibroids, non-cancerous growths that develop in the uterus, affect a staggering 80% of women by the age of 50. While many women may have asymptomatic fibroids that don’t require medical intervention, for others, these growths can lead to heavy menstrual periods, fertility issues, anemia, and bulk symptoms like a swollen abdomen. In this blog post, we explore the intricacies of uterine fibroids and shed light on ongoing clinical trials at WHP Clinical Research offering potential treatments for women facing heavy menstrual periods due to fibroids.

Understanding Uterine Fibroids: More Than Just Tumors

  1. Prevalence and Symptomatology:
  • While most women will develop uterine fibroids at some point, the critical question often becomes not ‘if’ but ‘why,’ especially as up to half of the cases can cause disruptive symptoms.
  • Common symptoms include abnormal bleeding, fertility problems, and anemia, prompting the need for medical attention.
  1. Nature of Uterine Fibroids:
  • Uterine fibroids, strictly speaking, are leiomyomas – muscle knots grown from uterine cells. Although they are categorized as tumors, they are non-cancerous growths.
  1. Role of Progesterone:
  • The cells of uterine fibroids are highly responsive to stimulation by progesterone due to increased receptors. Managing fibroids often involves strategies that either reduce progesterone levels or bind these receptors to inhibit further growth.
  1. Diagnosis and Growth Rates:
  • Large or rapidly growing fibroids are more likely to be diagnosed. Growth rates vary based on age and genetics, with most fibroids growing less than 20% in six months.
  • Pelvic examination and ultrasound play crucial roles in determining the pace of fibroid growth.

Exploring the Origins and Growth Factors:

  1. Influence of Steroid Hormones:
  • The origin of fibroids is assumed to be abnormal cells, and their growth is significantly influenced by steroid hormones, including estrogen, progesterone, and testosterone.
  1. Role of Growth Factors:
  • Local uterine growth factors, particularly Transforming Growth Factor β (TGF-βs), are pivotal in fibroid growth. Understanding these factors, including TGF-β1, TGF-β2, and TGF-β3, sheds light on potential therapeutic targets.
  1. Uterine Matrix and Research Frontiers:
  • The presence of uterine fibroids is also attributed to the uterus forming a special matrix around abnormal cells, allowing the formation of these round-shaped tumors.
  • Ongoing research is exploring whether natural compounds like vitamin D and resveratrol can serve as preventatives or medical treatments that target the matrix causing uterine leiomyoma.


Understanding uterine fibroids involves unraveling the complexities of growth factors, hormonal influences, and diagnostic approaches. As research continues to advance, clinical trials offer hope for innovative treatments that may provide relief to women experiencing heavy menstrual periods due to uterine fibroids. If you find yourself at the intersection of curiosity and concern regarding uterine fibroids, exploring what is new in the field with a WHP Health Provider could be a step toward a brighter and more informed path to wellness.


Suzanne Trupin, MD, Board Certified Obstetrician and Gynecologist and owner of Women's Health Practice, Hada Cosmetic Medicine, and Hatha Yoga and Fitness

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