This Hormone Treatment Also is and Estrogen and an Anti-Estrogen

Menopause and perimenopause treatments requires on going management, individual evaluation, and alternatives that change as you transition through menopause. A relatively new medication, Duavee, had been off the market due to production problems and it is once again back in pharmacies as a possible alternative for you.

Some women need anti-estrogen with their estrogen treatment!

A brand new concept in menopausal therapy came available to provide just that sort of treatment a few years ago called Duavee.

This compound was a novel combination of the estrogen product Premarin, a proprietary mix of hormones that are mostly estrogen, with a SERM (has agonist and antagonist properties) compound bazedoxifene which is, because of the physiological principal of antagonist, and antiestrogen.

The bazedoxifene component is effective for bone health, helps to protect the uterine lining from cancer, and is effective for decreasing the risk of breast cancer in some studies.

We at at Women’s Health Practice had been excited to be in the clinical trials looking at the effectiveness of this medicine for flash and osteoporosis trails. To date it remains as a novel estrogen-based drug for women to treat moderate-to-severe vasomotor symptoms associated with menopause as well as prevent postmenopausal osteoporosis.

The compound contains 20 mg of the bazedoxifene and new longer term data from a 7 year study showed that it is very safe over the many years. It did have a small effect on protecting against spine fractures when used by itself, and only a small effect on bone density as well as no protection against hip or wrist fractures. The combined drug 2 year data was released and it showed there was no risk of uterine or breast cancer or endometrium For optimizing women’s health in menopausal years, individual care is important understanding what you are most at risk for, what screening tests are important, and what symptoms you want to treat.

However, some women on this will still have suboptimal hormonal health if they are low in testosterone. So that even when on unusual compounds such as this, you may want your hormone levels checked, and may still be a candidate for bioidentical hormone therapy with BioTE pellets.